- Leslie K. Ferrarelli
In addition to its role in stimulating appetite, the hormone ghrelin and its receptor, GHS-R1a, are implicated in cognition. Ribeiro et al. found a role for ghrelin-independent GHS-R1a signaling in learning in mice. Treating mice with an inverse agonist of GHS-R1a impaired spatial and contextual memory formation. Thus, the use of ghrelin receptor–blocking therapies, which have been proposed for treating metabolic disorders, acromegaly, cancer, and alcoholism, may also have cognitive side effects.
Sci. Signal. 14, eabb1953 (2021).
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